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These studies have shown that triptolide can exert anti-RA activity through a variety of pathways and can be used as a potential therapeutic agent for RA

Biochim Biophys Acta 1863:29772992

Stryer, eds., Biochemistry, 8th ed, W.H

One prominent example is the androgen-dependent upregulation of members of the E-twenty-six (ETS) family of transcription factors by gene fusions between the AR-regulated TMPRSS2 gene promoter and the coding region of the ETS family members erythroblast transformation-specific (ERG) and ETS variant 1 (ETV1), which have been estimated to occur in 50% of prostate tumors 122,123,124

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