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T helper 1 (Th1) anti-inflammatory cytokines IL-4 and IL-10 are involved in the maintenance of homeostasis and, in particular, in controlling pro- and anti-inflammatory cytokines involved in infectious, allergic and autoimmune diseases

They achieve tumor-selective transport via FR/ and PCFT, reducing RFC-mediated uptake by normal tissuesthis represents a fundamental mechanistic improvement over traditional antifolates (e.g., MTX and PTX)

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