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Inhibition of the deacetylase function of sirtuin-2 can enhance the acetylation of -tubulin and facilitate the clearance and transport of misfolded protein

Supporting this, Wang et al (110) found that TSA notably improved cardiac function in two-kidney, two-clip (2K2C) hypertensive rats [reducing left ventricular end-diastolic pressure and increasing ejection fraction and left ventricular fractional shortening (LVFS)], while attenuating myocardial hypertrophy and fibrosis, independent of its antihypertensive effect (no notable impact on blood pressure) (110)

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This cationic amino acid transporter is found mainly in intestinal and renal cells, but y + LAT1 is also expressed in the lungs, spleen, circulation lymphocytes, and macrophages

Acknowledgments We thank the Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP) grants numbers 2020/14426-3 and 2024/18725-6 and Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq) grant number 306023/2022-9 and Fundao Coordenao de Aperfeioamento do Pessoal do Ensino Superior, CAPES), from Brazil Finance code 001