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In addition, presence of high concentrations of polyunsaturated fatty acids in the brain enhances their peroxidation and generation of toxic products which further causes degeneration of the cells harboring them or in vicinity 22

Two parallel pathways connect glutamine metabolism and mtorc1 activity to regulate glutamoptosis

Furthermore, if GSH efflux stimulation was abolished with the G1228D mutant, the basal GSH transport was not, suggesting also that the mechanism of stimulated GSH transport is different from the non-stimulated one

Bhardwaj JK, Paliwal A, Saraf P, Sachdeva SN

I.VizmanosJ

Rather, porphyrin binding and consequent ATPase activity was strongly enhanced in the presence of GSH (Wang et al