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Clinical studies show that while GLP-1 peptides like semaglutide and tirzepatide primarily reduce fat mass, some lean muscle is lost as well

JAMA 2013;310:243542

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By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis via the salvage pathway, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis, fat oxidation, and metabolic flexibility [3]