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Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells

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Its molecular formula is C10H11N2+ with a molecular weight of 159.21 g/mol

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Notably, proIGF-1Eb and proIGF-1Ec did not appear to be accumulated in the cytosol, and the molecular weight of proIGF-1Eb or proIGF-1Ec in the ER and nuclear fractions corresponded to that of proIGF-1s without signal peptide (5.3 kDa) (Fig