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Interestingly, in contrast to growth hormone insensitivity (GHI), the IGF-I deficient animals are neurologically impaired, as was also reported in a single patient with a defect in the IGF-I gene[40]

doi: 10.1177/1352458515616701 26 RotsteinDSolomonJMSormaniMPMontalbanXYeXYDababnehDet al

Are pediatric brain tumors on the rise in the USA

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Thus, the results of the studies show that spermidine has the potential to prolong life, protecting both the nervous and cardiovascular systems (Reference Li, Tian and Guo89)