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10.1016/j.cca.2025.120525 49 WangN.ShaoH.ChenY.XiaF.ChiC.LiQ.et al (2017)

Epidemiological modifiers of non-alcoholic fatty liver disease: focus on high-risk groups

Nucleic Acids Res 36 , 39263938 (2008)

Key Takeaway: The ratio of reduced to oxidized glutathione in your cells is a primary indicator of cellular health

Similar to the NNMT knockdown experiments, NNMT inhibitors reversed obesity by modulating NAD + rescue and the pathways mediated by SAM

Reported common symptoms upon keto-induction include headache, light headedness, fatigue, lethargy, brain fog, decreased exercise capacity, mood changes, constipation, muscle cramps, diarrhea and halitosis