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Li J, Wen M, Zhang S, et al

159 showed improved drug delivery and significant antibacterial activity with chitosan nanoparticles, a natural polymer typically found in the exoskeleton of crustaceans, such as shrimp

If this is chemical leukoderma, removing the trigger is the first step

Here's what the research shows: That last point is significant

This resistance is contradictory because echinocandins enzymatic target, -1,3-glucan synthase, is crucial for Cryptococcus and has been shown to be strongly biochemically inhibited by them (Thompson et al., 1999