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However, portal insulin delivery is also an essential co-player in the regulation of the GH/IGF-I axis by affecting and regulating hepatic GH receptor synthesis, and subsequently altering hepatic GH sensitivity and IGF-I generation

qRT-PCR and immunoblot analyses confirmed robust overexpression of Chac1 in liver (Supplemental Figure 1B and Figure 1C)

Life Sci 148:4152 Ahn RW, Chen F, Chen H, Stern ST, Clogston JD, Patri AK et al (2010) A novel nanoparticulate formulation of arsenic trioxide with enhanced therapeutic efficacy in a murine model of breast cancer

Ipamorelin is a selective ghrelin receptor (GHS-R1a) agonist studied for pulsatile growth hormone release that mimics the body's natural GH release pattern