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It plays key roles in mammalian metabolism and physiology, with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain

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Forouzanfar et al

234 DSF/Cu treatment also profoundly impairs mitochondrial homeostasis, increasing the free iron pool and exacerbating lipid peroxidation, ultimately culminating in ferroptosis triggered by p62 phosphorylation-mediated NRF2 accumulation

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