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These phases are shaped by the paradigm of selecting an initial hit compound from a molecular library, which is then iteratively elaborated into a lead series with improved potency, selectivity, and drug-like properties 15

Transcripts were assembled and quantified using Stringtie 84,85 , and differential expression analysis was performed using edgeR on genes with a CPM of at least 1 in all samples 86,87

GSH degradation is a key determinant of GSH homeostasis, in addition to its biosynthesis [8]

& Kim, K.-S

Effects of oral -lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial

Each unit holds more, which suits larger target masses and keeps the total liquid volume within a small vial