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Graphical Abstract Graphical Highlights NAD+ depletion is a hallmark of MASLD and ALD, driving lipid accumulation, oxidative stress, ERS, inflammation, autophagy and fibrosis

Selenium enriched mushrooms show higher antioxidant activity while reducing lipid peroxidation substantially

Energy drinks often contain high levels of caffeine and other stimulants, which can lead to increased heart rate, high blood pressure, insomnia, anxiety and digestive issues when consumed in excess

HBM, human breast milk

One of the primary functions of Glutathione is to assist in the detoxification process

Roles for glutathione transferases in antioxidant recycling