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The corresponding cysteine in ATPS of the diatom Phaeodactylum tricornutum has been described to be sensitive to oxidation by H 2 O 2 , as well as several other less conserved cysteine residues (Rosenwasser et al., 2014)

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Impairment of mismatch repair, homologous recombination deficiencies associated with BRCA1/2 loss, polymerase proofreading defects (e.g., POLE mutations), and carcinogenic insults such as tobacco smoke, ultraviolet radiation, and prior chemotherapy collectively accelerate mutation accumulation and diversify tumor cell populations (6668)