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People with certain allergies Natural spermidine supplements (e.g., Omre) are often derived from wheat germ, which contains a protein that can cause serious adverse effects in people with a gluten or wheat allergy hives, rash, asthma, anaphylaxis.25 Rice germ is another ingredient that you might see in a spermidine supplement, and it too can cause the same adverse effects.26 If you're allergic to either ingredient (or another component used in a particular formulation), you should avoid the product that contains it

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Disruptions in mitochondrial function can lead to altered cellular energy metabolism, increased production of ROS, and impaired cellular responses to mechanical stress

The human body is, however, well equipped with a variety of antioxidants, both endogenously produced and exogenously obtained, that serve to counteract the deleterious effect of oxidative stress

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First, ferroptosis-related compounds, such as Erastin, RSL3 and ML162, can lead to significant off-target effects and additional tissue damage, similar in viral infections