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Sirtuins in epigenetic regulation

However, it was concluded that the progression of CKD is associated with a higher oxidative stress, with lipid peroxidation more pronounced in haemodialysis patients and protein oxidation in peritoneal dialysis patients

March 16, 2026

The proposed mechanism involves selective stimulation of fat breakdown (lipolysis) and suppression of fat formation (lipogenesis) via direct effects on adipose tissue, without the growth hormone-like systemic effects