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The combination of LDHA inhibitors with PD-1 blockers significantly inhibits lactate production and downstream lactylation modifications, synergistically enhancing anti-tumor immune activity (115)

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228 Although blood is the most commonly used sample for mtDNA testing, it is also advisable to assess mtDNA in urine and other affected tissues due to the possibility of tissue-specific mutations

Hum Mol Genet 17: 27902802 Ayer A, Tan SX, Grant CM, Meyer AJ, Dawes IW, Perrone GG (2010) The critical role of glutathione in maintenance of the mitochondrial genome