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Brown University

Data availability Included in article

Appropriate iron levels promote M2 polarization of macrophages, inducing secretion of cytokines CCL17 and CCL22 that enhance ECM secretion [73], critical for increasing ECM deposition and promoting wound repair [74]

A 14-month-old girl developed severe B12 deficiency

This multi-level approach is vital to elucidate pathogenesis, enable prevention, and advance microbiota-targeted treatments, ultimately aiming to modify the disease course, improve prognosis, and enhance patient quality of life