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Experiments utilizing various RNAi drugs and small molecule inhibitors targeting NNMT have highlighted its potential as a therapeutic target for preventing and treating diseases associated with MetS

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However, certain molecules, such as erastin and sulfasalazine can inhibit system XC and cause the depletion of cellular cysteine, leading to the impairment of the intracellular GSH homeostasis and ultimately, intracellular GSH deficiency and ferroptosis (44,45)

Altered gene expression along the glycolysis-cholesterol synthesis axis is associated with outcome in pancreatic cancer

Huang, L., Sayer, J