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FIGURE 6 3.3.1 Curcumins function in microRNA control Curcumin influences the transcription and stability of miRNAs by upregulating tumor-suppressive miRNAs and downregulating oncomiRs, alters the expression of lncRNAs such as Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) and Urothelial Carcinoma-Associated 1(UCA1), and modifies the networks of circRNAs, specifically the miRNA sponging axes

It is known to induce CYP2E1 activity by protein stabilization (18)

Because they utilize completely separate mechanisms (angiogenesis vs

The reaction mix included gene-specific primers for TGF- and GAPDH (Table 1) and SYBR Green dye for fluorescence detection

Thanks to the thiol groups in the cysteine (Cys) residues, glutathione and thioredoxin participate in the reduction of oxidized proteins

Nrf2 is known to induce many antioxidant enzymes via the antioxidant response element in their promoters, including enzymes involved in the synthesis and metabolism of glutathione