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Chronic stress and the resulting hyperactivity of the HPA axis have been shown to lead to a decrease in serotonin levels in the brain, particularly in regions such as the prefrontal cortex (PFC) and hippocampus, which are essential for mood regulation

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While the precise mechanisms linking these metabolic alterations to fibrotic remodeling remain to be fully elucidated, current studies strongly support amino acid metabolism as a central regulatory axis in fibrosis initiation and progression

Inflammatory modulation: animal models of experimental colitis (TNBS, DSS), toxic hepatitis and joint damage documented reduction of pro-inflammatory cytokines (TNF-, IL-6, IL-1) and improvement of histological lesion scores

2006;31(10):E3026

Maintaining proper vitamin levels is important