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Specific componentsuPA, uPA receptor (uPAR), and PAI-1are strongly associated with breast cancer progression

The doxorubicin cardiotoxicity studies are particularly noteworthy because this chemotherapy drug causes a type of heart damage that closely resembles natural cardiomyopathy

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However, in a separate real-world study of 63 virologically suppressed people with HIV in Italy who switched to DOR/3TC/TDF from any prior ART regimen (mostly regimens containing an NNRTI [47%] or PI [32%] as the only anchor agent), a non-statistically significant median weight increase of 0.55 kg was observed over 12 months of follow-up [26]

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