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Lovblad K, Ramelli G, Remonda L, Nirkko AC, Ozdoba C, Schroth G

Early evidence for the potential efficacy of this route was published in 1999, where 18 patients with B12 deficiency treated exclusively with 712 days of 2 mg of sublingual cobalamin daily had 4 times higher B12 levels compared to pre-treatment, reaching therapeutic ranges ( There have also been further studies comparing treatment outcomes from the sublingual route to the more established IM and oral routes

Vitamin B12 is a water-soluble vitamin necessary for cell growth and cell reproduction

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CD47 on MM cells can bind to SIRP on macrophages, resulting in an inhibition of phagocytosis [74]

Here are some of the main causes of vitamin B12 deficiency