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2) and may ultimately provide a safer treatment option

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These bile acids act as signaling molecules that activate the FXR and the G protein-coupled bile acid receptor 1 (TGR5), pathways known to regulate lipid metabolism, promote cholesterol efflux, increase energy expenditure, and reduce hepatic steatosis and atherosclerotic risk (140, 145, 155, 156)

On infection with adenoviral vector expressing Cre recombinase (Ad-Cre), Fh1 fl/fl cells, which lost FH activity, underwent proliferation arrest, whereas the uninfected cells continued to proliferate (Fig

This work was supported by the National Health and Medical Research Council of Australia (NHMRC) Project grants (1006141, 10305133, 1086887, and 1095215)

to better her Urdu-speaking skills, she watched the Pakistani television series Zindagi Gulzar Hai