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Moreover, SLC7A11 and cyclin-dependent kinase inhibitor 1A (CDKN1A) gene expression is stimulated by the p53DPP4 interaction, thereby inhibiting ferroptosis (82)

doi:10.1002/nbm.966

Nature 511:319325

Clinical trials investigating the effects of small-molecule antioxidants on the prevention or treatment of chronic diseases in humans have largely yielded unsatisfactory outcomes (Halliwell 2022)

Impaired acidification, fusion defects and reduced endosomeautophagosomelysosome pathway flux compromise the clearance of pathogenic aggregates, and raising cellular cAMP or free zinc has been proposed as a strategy to restore lysosomal pH and proteolytic capacity in affected neurons 166