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Introduction The liver has a central role in metabolism, because of both its anatomic placement and its many biochemical functions The liver receives venous blood from the intestine: thus all of the products of digestion, ingested drugs and other xenobiotics reach it and may be further metabolized before entering the systemic circulation

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Finally, liver sections were mounted in Fluorescent Mounting Medium (DAKO, Glostrup, Denmark)

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PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway