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Chemico-Biol Interact 286:132140

doi: 10.1016/j.abrep.2024.100531 139

Preclinical and clinical pharmacology studies have also implicated the glutamatergic system in these disorders through known and suspected drug mechanisms (5456)

Variations in genes associated with inflammation, oxidative stress response, and neuronal function have been linked to increased susceptibility to neuropathy in diabetes patients

Dahlen, S.-E

Under physiological conditions, redox homeostasis is maintained by coordinated endogenous antioxidant systems, including the Nrf2-Keap1 signaling pathway, the glutathione (GSH) system, superoxide dismutases (SOD1 in the cytosol and SOD2 in mitochondria), catalase, glutathione peroxidases (GPXs), and the thioredoxin/peroxiredoxin network (34)