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JHU083 has also demonstrated excellent therapeutic efficacy in preclinical models of IDH-mutant gliomas and significantly reduces mTOR signaling (Yamashita et al., 2021)

Although both chronologic age and comorbidities may be considered surrogates of functional reserve, their accurateness as single parameters in defining a patient overall well-being is limited

Under 412.88(a)(2), we would limit new technology add-on payments to the lesser of 65 percent of the average cost of the technology, or 65 percent of the costs in excess of the MS-DRG payment for the case

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These observations have prompted growing interest in non-hormonal contributors to hypothyroidism, particularly the role of the gut microbiota

Importantly, Berger et al