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Some studies have found that the use of Lactobacillus rhamnosus GG not only fails to reduce the incidence of VAP but may also increase the risk of adverse events such as bacteremia (189)

PMID: 206 KatkowskaMGarbaczKKusiakA

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The compound has not been tested, approved or marketed as a finished medicinal product

Taken together, GLP-1based and dual GLP-1/GIP agonists represent a biologically plausible and clinically feasible strategy for repurposing as adjunctive neuroprotective therapies in PD, although further preclinical and clinical studies are needed to define their optimal dosing, treatment duration, and combinational approaches to ensure sustained neuroprotection (Figure 2)

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