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Acknowledgements We are very grateful to Professor Rafael Radi (Montevideo, Uruguay) for his helpful discussions and revision of this manuscript

The downregulation of CBS expression resulted in the decrease of antioxidant proteins NRF2, MnSOD, TRX-2, and GPX4, and the increase of GR and Catalase, signifying a disturbance in the equilibrium between cellular oxidative and antioxidative systems, thereby inducing oxidative stress (Fig

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HCG itself is not established as an effective obesity treatment, and very low-calorie diets may come with side effects and risks