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Additionally, the researchers aimed to explore the relationship between whole-blood serotonin levels, caffeine consumption, and the frequency of sleep and mood disorders

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The permeability of mitragynine across the intestinal barrier was also measured using in situ single-pass perfusion technique in rats ( In situ perfusion technique enables measurement of barrier permeability in an intact functional barrier with membrane transporter machinery in place ( P eff was 111 10 6 cm/s