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Such circumstances have directed healthcare systems toward being more reactive than proactive, prioritizing treatment of illnesses over prevention, ultimately resulting in massive expenses to medically intervene (114116)

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The downregulation of macrophages activity through the overexpression of CD47 is already known as a mechanism for cancer cells to escape the immune system

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This effect may be attributed to the blood glucose-lowering effect of metformin, which maintains a glucose-deprived environment unfavorable for cancer cell growth, thus increasing the efficacy of chemotherapy

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