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Additionally, exposure to toxins, liver damage, illness, and genetics can disrupt and impact glutathione production

doi: 10.18632/aging.205049 30 KongNChenXFengJDuanTLiuSSunXet al

Bladder cancer and arsenic through drinking water: a systematic review of epidemiologic evidence

In: Hypertens Cardiovasc Dis Asia, Springer, pp 285298

however, glutathione is significantly depleted in hepatocytes during SNMP, which is probably attributed to the hepatocytes inability to overcome the threshold energy necessary for glutathione synthesis under subnormothermic conditions (145)