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This study reported that natural kavalactones, particularly kavain, showed significant inhibitory effects on edema induced by either formalin, serotonin, carrageenan or dextran on rat paws, as well as on UV light-induced inflammation of the rat skin [50]

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10.1093/toxsci/kfq279 88

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the -globin locus control region

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Membantu kerja enzim dalam tubuh

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Clinical Pharmacology & Therapeutics 2022: volume 111, issue 5, pages 1,0071,021

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Upon receptor activation, the plasma membrane extends pseudopods, forming a cup-shaped enclosure around the target

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