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Therefore, preoperative pretreatment with GnRH-a reduces fibroid volume and decreases the formation and number of intraglandular vessels, offering significant advantages in reducing intraoperative blood loss during myomectomy and shortening surgical duration

This suggests more robust or sustained expression and coordination among multiple CYP enzymes relevant to verapamil metabolism, including the metabolizing enzymes CYP2C8 , CYP3A4 and CYP3A5 , all of which are responsible for verapamil N -demethylation and were highly expressed in h-HepOrgs in DM (Extended Data Fig

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