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(2017) 2:e89160

10.1007/s11010-016-2885-9 288 SattlerR.XiongZ.LuW

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Finally, most studies evaluate the crude extract, which prevents the complete elucidation of molecular mechanisms of action and synergism between active metabolites (such as triterpenoids and flavonoids), limiting the development of optimized phytotherapeutic therapies (Table 3)

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In STEP 1 [1] , the largest trial with 1,961 participants [1] , patients receiving semaglutide 2.4 mg weekly achieved an average weight loss of 14.9% over 68 weeks, compared to 2.4% with placebo (Wilding et al., NEJM, 2021)