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Nature 488 , 404408 (2012)

10.1016/j.bbagen.2013.02.009 51 GopalS.BorovokI.OferA.YankuM.CohenG.GoebelW.et al

This approach prevents the moisture fluctuations that can compromise skin elasticity and barrier function

Abstract Background The insulin/IGF-1 signaling pathway has a major role in the regulation of longevity both in Caenorhabditis elegans and mammalian species, i.e., reduced activity of this pathway extends lifespan, whereas increased activity accelerates the aging process