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FreyIMRubio-AliagaISiewertASailerDDrobyshevABeckersJet al

L.StannardB.ButlerA.AcciliD.SauerB.et al (1999)

Haibo Xu, [email protected] These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Additionally, in microglia, LRRK2 exerts a negative regulatory effect on -syn clearance by downregulating the early endocytosis pathway, as LRRK2 -knockout microglia exhibit enhanced -syn uptake and clearance associated with increased Rab5-positive early endosomes and improved Rab5-dynamin 1 coordination (195)