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The ghrelin/GHRP system modulates pulse timing and frequency by acting at both hypothalamic (stimulating GHRH neurons, inhibiting somatostatin neurons) and pituitary (direct somatotroph stimulation) levels

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10.3389/FCELL.2020.564601 125 Saint-GermainE.MignaccaL.VernierM.BobbalaD.IlangumaranS.FerbeyreG

While traditional thrombolytic therapy, such as recombinant tissue plasminogen activator (tPA), has shown promise for clinical improvement, existing drugs face several limitations, including a short half-life and risks such as hemorrhage and cerebral edema