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"Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution"

Targeting Ferroptosis to Iron Out Cancer

10.1016/j.jnutbio.2017.10.011 166

Funding This work was funded by RETOS projects Programme of Spanish Ministry of Science, Innovation and Universities, Spanish State Research Agency (AEI/10.13039/501100011033), co-funded by the European Regional Development Fund (Grant SAF2015-67538-R and PID2019-104012RB-I00), EU-H2020 Programme (ERC-2014-STG-638891), Excellence Network Grant from MICIU/AEI (SAF2016-81975-REDT), a Ramon y Cajal Award from MICIU/AEI (RYC-2013-13546), a Lab Grant from the Spanish Association Against Cancer Research Scientific Foundation (AECC), Beca de Investigacin en Oncologa Olivia Roddom, and FERO Grant for Research in Oncology (to AE)

It was reported that TLR receptors present in epithelial cells are stimulated by pathogens and trigger the NF-kB and p-c-Jun N-terminal kinases (JNK) pathways, leading to the release of proinflammatory cytokines and chemokines

Reduced apoptosis is often associated with the development of cancer, and finding agents that can restore programmed cell death in cancer cells is considered a potential therapy for cancer