napqi glutathione mechanism File:Acetaminophen metabolism.jpg PharmGKB summary: Pathways of acetaminophen

PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses PMC 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Simplified scheme of APAP metabolism, leading to the formation of NAPQI Download Scientific Diagram How acetaminophen is metabolized in the liver A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Solved The following figure shows the metabolism of the

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