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Cisplatin and beyond: Molecular mechanisms of action and drug resistance development in cancer chemotherapy

10.1002/1873-3468.14359 FEBS Lett

doi: 10.1620/tjem.221.287 64 Seron-FerreMValenzuelaGJTorres-FarfanC

267 PalazzoliFCittiCLicataMVilellaAMancaLZoliMet al

Measurement of ROS, lipid peroxidation, and mitochondrial integrity 5 10 5 cells were first seeded onto a 6-well plastic plate overnight, before incubation with 100 g/mL of PM(2.5) for 6 h

These substitutions confer DPP-IV resistance and enhanced GHRH receptor binding affinity while preserving a pulsatile, short-acting pharmacokinetic profile in deliberate contrast to the DAC-conjugated variant designed for prolonged receptor occupancy