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severe K + depletion disrupts HK2-dependent glycolysis, triggering an energy stress response

Cell Mol Neurobiol 43(7):31153136 Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV (2013) Levels of soluble apolipoprotein E/amyloid- (A) complex are reduced and oligomeric A increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples

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But the researchers discovered that after an overdose, liver cells turn on a gene that shuttles desperately-needed cysteine into the cell but pumps glutamate out, until eventually glutamate levels start to run low, too

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Differential analysis of core-fucosylated glycoproteomics enabled by single-step truncation of N-glycans