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Hydrocodone causes a reduction in motility associated with an increase in smooth muscle tone in the antrum of the stomach and duodenum

Detection was carried out with positive polarity, in selected reaction monitoring (SRM) mode, selecting the following ions: AX 366.4, 114.0 (22eV), 349.0 (6eV)

Predicted physicochemical properties supported its hydrophobic character and oral bioavailability, suggesting it is a metabolically stable and BBB-permeable molecule [2]

These included inhibition of adhesion and motility, strong stimulation of oxidative stress response, disruption of iron homeostasis, blocking of energy production (both aerobic and anaerobic), and affecting quorum sensing detection

Brandon Colby, MD, Founder of Sequencing and author of Outsmart Your Genes