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Finally, we connect these mechanistic insights to both established and emerging therapeutic strategies, emphasizing the potential value of stage-specific and mechanism-oriented interventions

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Thus, the increased sensitivity to RSL3 induced by LDHB silencing in A549 cells is not solely dependent on the CoQ-associated defense mechanism, which is consistent with our previously published study showing that LDHB silencing also affects the GSH-associated defense mechanism in KRAS -mutated lung cancer 24

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A responsive fluorescent probe for detecting and imaging pyruvate kinase M2 in live cells

Mild gastrointestinal adjustment transient nausea or altered bowel patterns, generally offset by BPC-157 s gastroprotective action