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Konzo: a distinct disease entity with selective upper motor neuron damage

While NF-B is implicated in inflammatory mechanisms leading to apoptosis, it also possesses the capability to enhance BDNF expression (Lipsky et al., 2001) offering a multifaceted interplay for ALA in NMDA receptor-mediated neuroprotection in the context of cerebral ischemia (Lipsky et al., 2001)

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The inhibition of the Wnt signaling pathway is related to the severe neurodegenerative progress induced by PQ, including demyelination (Inestrosa and Arenas, 2010)

Sources of disulfide reducing power in eukaryotic organelles Eukaryotic evolution of organelles, including nuclei, mitochondria, endoplasmic reticula, and plastids, each with differing restrictions on molecular exchanges with the cytosol, required development of specialized subcellular disulfide reductase machineries

[PubMed: 25631887] For many workflows, labs keep a master vial protected from routine handling, and prepare smaller working aliquots to reduce exposure