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Senescent cells, through the secretion of SASP factors into their environment, influence neighboring non-senescent cells and the extracellular matrix (ECM), leading to inflammation, fibrosis, and programmed death of healthy cells, while simultaneously becoming resistant to apoptosis [34]

206 YinJ.SakamotoK.ZhangH.ItoZ.ImagamaS.KishidaS.et al (2009)