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Despite promising preclinical data, the translational potential of polyphenols to human clinical settings remains constrained by their poor bioavailability, limited bloodbrain barrier (BBB) penetration, and rapid metabolic degradation (Figueira, Menezes, et al

Andreini, C

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Systemic autoimmune diseases, such as SLE and RA, exhibit widespread activation of the immune system, affecting multiple organs and tissues, and their pathogenic mechanisms involve self-antigen exposure and immune complex deposition (22)

GPX4 expression was significantly reduced in SLE neutrophils but not in other immune cells, whereas reduced glutathione levels have been documented in patients with SLE before

From case reports of severe inflammation and liver injury, to regulatory alerts about contamination the hazards outweigh the unproven benefits