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The p53 pathway in glioblastoma

Limited Depth of Penetration: Cold lasers have limited depth of penetration, making them less suitable for deep-seated conditions

Similarly, oral administration of steviol glycosides at doses up to 1,880 mg/kg for 4 weeks caused only mild increases in oxidative damage and chromosomal abnormalities in mice, whereas no genotoxic effects were observed at doses as high as 8,000 mg/kg in vivo (Orellana-Paucar, 2023)