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[1] [4] Published phase 2 trial data (Jastreboff et al., NEJM , 2023) reported dose ranges from 1 mg up to 12 mg weekly, with higher doses associated with greater weight loss but also increased rates of gastrointestinal side effects

The study was carried out in 112 subjects with moderately severe CTS, comparing the effectiveness of a multivitamin B preparation (Vit B6 150 mg, Vit B1 100 mg, Vit B12 500 g daily) for 90 days with a fixed association of ALA (600 mg/day) and gamma-linolenic acid (GLA, 360 mg/day)